March 19 , 2021
· Patent 01 | Accompany Peptides 2021/3/19
We have developed a technology named “Accompany Peptides”, wherein the clinical samples will be mixed with a set of synthesized peptides beforehand and afterwards sent for sample preparation. In this way, the sample loss during preparation will be partly distributed to the accompany peptides. This design not only decreases the difficulties of sample handling, but also assures resultant reliability as the deliberately designed accompany peptides do not bring to interferences in the mass spectrometry detection.
Proteomics resolves to analyze proteins in a systematic way to profile compositions and changes of biology. Mass spectrometry-based proteomics has been largely applied to biological research and has set foot to clinical studies. Due to the rarity and special requirements of clinical samples, proteomics of low-amount of samples such as single cell proteomics are facing huge challenges, with a key issue in sample loss during preparation, which further affects analysis depth and accuracy.
· Patent 02 | DIAT 2020/11/17
DIAT is data analytics of molecular omics data structure based on data-independent acquisition of mass spectra. The mass spectrum data structure is the DIAT tensor data generated from the raw data of the mass spectrum. The DIAT tensor data is highly complete, easy to read and fast to read. The size of the DIAT file is only one tenth of the mzXML file. Through the visualization of the pooled DIAT file image, the DIA mass spectrum data can be directly observed and used directly, avoiding the operation of extracting ion chromatographic peaks with a large amount of calculation. It allows the direct modeling into a computer deep learning model for clinical sample classification based on this file format. With the increase in the quality and quantity of DIA data, the potential of the technology of the present invention in clinical diagnosis can be foreseen, and it will provide a new solution for disease classification and diagnosis.
· Patent 03 | PulseDIA 2019/12/17
The present invention provides a MS-based proteomic method using pulse data independent acquisition.The invention solves the technical problems that due to the limitation of the number of isolation windows, the peptide precursor ions shadow each other more in the mass spectrometer due to the insufficient separation degree, resulting in the low degree of separation of peptide and fewer protein identifications.