OmniProt™ – Nanoparticle-Based Kit for Plasma Proteome Enrichment

OmniProt™ Elevates your research!

OmniProt™ implements a nanoparticle-based low-abundance protein enrichment strategy for plasma and serum samples, enhancing proteome coverage and improving the consistency of quantitative mass spectrometry analysis.

OmniProt™ workflow

OmniProt™ is well-suited for lab-scale studies and rapid method development. Its flexible workflow allows customization at each step, supporting precise experimental control and accelerated optimization without reliance on fixed protocols. A reference protocol is provided below. [1]

OmniProt™ working principle

· Dynamic protein corona - powered selective protein enrichment：

OmniProt™ uses nanoparticles that form a dynamic protein corona when exposed to plasma or serum, creating a biological interface that enables selective enrichment of proteins across various abundance levels. [1]

By engineering a protein corona through nanoparticle-plasma interactions, OmniProt™ significantly enhances the identification of low- and medium-abundance proteins in human and mouse plasma/serum samples.

Baize will tell the truth！

Researchers at Westlake University developed Baize, an open-access software tool designed to assess contamination from platelets, erythrocytes, and coagulation-related proteins in nanoparticle-based plasma proteomics, ensuring data quality and interpretability.

https://www.guomics.com/Baize/

More details

[1] A comprehensive evaluation of OmniProt's performance has been published in a preprint on bioRxiv. We invite the community to review the detailed analysis and share feedback for improvement. 

Read the article.